Preheat the oven to 350°F (175°C).

In a large mixing bowl, combine the ground beef, Stove Top stuffing mix, water or beef broth, chopped onion, egg, garlic powder, Worcestershire sauce, salt, and pepper.

Mix until just combined, being careful not to overwork the meat.

Transfer the mixture to a greased loaf pan and shape it into a loaf.

Bake in the preheated oven for 1 hour, or until the internal temperature reaches 160°F (70°C).

Let the meatloaf rest for 10 minutes before slicing.

Slice and serve warm, with your favorite sides.