Preheat your oven to 350°F (175°C).
In a large bowl, combine ground chicken, breadcrumbs, Parmesan cheese, egg, garlic powder, onion powder, salt, and black pepper. Mix well until fully combined.
Fold in the diced ham, diced Swiss cheese, chopped parsley, Dijon mustard, and Worcestershire sauce until evenly distributed.
Transfer the mixture to a loaf pan and shape it into an even loaf.
Bake in the preheated oven for 50-60 minutes, or until the internal temperature reaches 165°F (74°C).
Remove from the oven and let it rest for 10 minutes before slicing.
Slice and serve the meatloaf warm, optionally with additional mustard or your favorite sauce.