Preheat your oven to 350°F (175°C).
In a large skillet over medium heat, brown the ground beef until fully cooked, about 7-10 minutes.
Drain any excess grease from the skillet, if necessary.
Add the garlic powder, onion powder, diced tomatoes with green chilies, and season with salt and pepper.
Stir in the cooked elbow macaroni and mix well.
Pour in the milk and half of the shredded cheddar cheese; mix until combined.
Transfer the mixture to a greased 9x13 inch baking dish and spread it out evenly.
Sprinkle the remaining cheddar cheese and breadcrumbs over the top.
Bake in the preheated oven for 25-30 minutes, or until bubbly and golden brown on top.
Remove from the oven and let it rest for 5-10 minutes before serving.